FIRMAN GUSTINA; AMELINDA NUR AMALINA; FAJAR NUGRAHA; FITRIAH HANY. How Does Metformin as First-Line Therapy Impact Long-Term Cardio- Vascular and Metabolic Outcomes in Patients with Type 2 Diabetes Mellitus over A 5-Year Period ? : A Systematic Review. The International Journal of Medical Science and Health Research, [S. l.], v. 13, n. 2, p. 39–84, 2025. DOI: 10.70070/8c4yz749. Disponível em: http://internationalmedicaljournal.org/index.php/ijmhsr/article/view/255.. Acesso em: 15 apr. 2026.