The Analysis Study Effect of Intermittent Fasting on Female Reproductive Hormones and Menstrual Cycle: A Comprehensive Systematic Review
Keywords:
intermittent fasting, female reproductive hormones, menstrual cycleAbstract
Background: Intermittent fasting (IF) has surged in popularity as a dietary approach for weight management and metabolic health, yet its effects on female reproductive hormones and menstrual cycle regulation remain an area of growing scientific inquiry. This systematic review aims to evaluate the influence of IF on female reproductive hormones and menstrual cycle. Methods: The study followed PRISMA 2020 guidelines, reviewing English-language publications from 2015 to 2025. Editorials, duplicate reviews from the same journal, and papers lacking a DOI were excluded. The literature search was conducted using PubMed, SagePub, SpringerLink, and Google Scholar. Result: A total of 2,172 articles were initially identified through online databases (PubMed, SagePub, SpringerLink, and Google Scholar). After three rounds of screening, eight relevant studies were selected for full-text analysis. Conclusion: IF presents both potential benefits and risks for female reproductive health. While it may aid in weight loss, improve insulin sensitivity, and reduce inflammation, concerns remain about its effects on hormonal circadian rhythms and reproductive function. Individualized approaches that consider metabolic status, hormonal health, and lifestyle factors are essential for optimizing the benefits of IF while minimizing potential adverse effects on female reproductive hormones and menstrual cycles.
References
Brocchi A, Rebelos E, Dardano A, Mantuano M, Daniele G. Effects of intermittent fasting on brain metabolism. Nutrients. 2022;14(6):1275.
Mao Q, Yang Y, Liu Y, et al. The efficacy of platelet rich plasma in the treatment of erectile dysfunction: a systematic review and meta-analysis of randomized controlled trials. Aging Male. 2024;27(1):2358944. doi:10.1080/13685538.2024.2358944
Al Zunaidy NA, Al-Khalifa AS, Alhussain MH, Althwab SA, Mohammed MA, Faris ME. The effect of Ramadan intermittent fasting on anthropometric, hormonal, metabolic, inflammatory, and oxidative stress markers in pre-and post-menopausal women: A prospective cohort of Saudi women. Front Nutr. 2024;11:1437169.
Patterson RE, Laughlin GA, Sears DD, et al. Intermittent fasting and human metabolic health. J Acad Nutr Diet. 2015;115(8):1203.
Lessan N, Ali T. Energy metabolism and intermittent fasting: the Ramadan perspective. Nutrients. 2019;11(5):1192.
Shin BK, Kang S, Kim DS, Park S. Intermittent fasting protects against the deterioration of cognitive function, energy metabolism and dyslipidemia in Alzheimer’s disease-induced estrogen deficient rats. Exp Biol Med. 2018;243(4):334-343. doi:10.1177/1535370217751610
Velissariou M, Athanasiadou CR, Diamanti A, Lykeridou A, Sarantaki A. The impact of intermittent fasting on fertility: A focus on polycystic ovary syndrome and reproductive outcomes in Women-A systematic review. Metab Open. Published online 2025:100341.
ABU SALMA BM, THEKRALLAH F, QATAWNEH A, HASAN H, SHAWAQFEH S, ALTARAWNEH M. Effect of intermittent fasting on improve body composition and anthropometric measurements of women with polycystic ovarian syndrome. Rev Nutr Clínica Dietética Hosp. 2024;44(2). Accessed February 16, 2025. https://search.ebscohost.com/login.aspx?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=02116057&AN=178285753&h=XNg4QwuKBcuxI65%2Fkb0P3tI0z4ttNFL6LsVnTOI2GVvWnDjX%2BiDeI5Z6BRFyCvU6r8heRqhyjU%2FxvE0fLEZceA%3D%3D&crl=c
Alum EU, Obeagu EI, Ugwu OPC, Alum BN, Arinze ED, Ukaidi CUA. Exploring the Differential Impacts of Intermittent Fasting on Men and Women. Elite J Health Sci. 2024;2(5):37-44.
Albrahim T, Alangry R, Alotaibi R, Almandil L, Alburikan S. Effects of regular exercise and intermittent fasting on neurotransmitters, inflammation, oxidative stress, and brain-derived neurotrophic factor in cortex of ovariectomized rats. Nutrients. 2023;15(19):4270.
Martínez-Rodríguez A, Rubio-Arias JA, García-De Frutos JM, Vicente-Martínez M, Gunnarsson TP. Effect of high-intensity interval training and intermittent fasting on body composition and physical performance in active women. Int J Environ Res Public Health. 2021;18(12):6431.
Scarbrough C. The Effects of Intermittent Fasting on Female Athletes: A Systematic Review. Mississippi State University; 2023. Accessed February 16, 2025. https://search.proquest.com/openview/525e5fda39440b544da548b3879d96b0/1?pq-origsite=gscholar&cbl=18750&diss=y
Hooshiar SH, Yazdani A, Jafarnejad S. Does an alternate-day modified fasting diet improve premenstrual syndrome symptoms and health-related quality of life in obese or overweight women with premenstrual syndrome? A randomized, controlled trial. Front Nutr. 2024;10:1298831.
Nair PM, Khawale PG. Role of therapeutic fasting in women’s health: An overview. J -Life Health. 2016;7(2):61-64.
Li C, Xing C, Zhang J, Zhao H, Shi W, He B. Eight-hour time-restricted feeding improves endocrine and metabolic profiles in women with anovulatory polycystic ovary syndrome. J Transl Med. 2021;19(1):148. doi:10.1186/s12967-021-02817-2
Kim BH, Joo Y, Kim MS, Choe HK, Tong Q, Kwon O. Effects of intermittent fasting on the circulating levels and circadian rhythms of hormones. Endocrinol Metab. 2021;36(4):745-756.
Mattson MP, Longo VD, Harvie M. Impact of intermittent fasting on health and disease processes. Ageing Res Rev. 2017;39:46-58.
Stratton MT, Tinsley GM, Alesi MG, et al. Four Weeks of Time-Restricted Feeding Combined with Resistance Training Does Not Differentially Influence Measures of Body Composition, Muscle Performance, Resting Energy Expenditure, and Blood Biomarkers. Nutrients. 2020;12(4):1126. doi:10.3390/nu12041126
Moro T, Tinsley G, Longo G, et al. Time-restricted eating effects on performance, immune function, and body composition in elite cyclists: a randomized controlled trial. J Int Soc Sports Nutr. 2020;17(1):65. doi:10.1186/s12970-020-00396-z
Moro T, Tinsley G, Bianco A, et al. Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males. J Transl Med. 2016;14(1):290. doi:10.1186/s12967-016-1044-0
MORO T, TINSLEY G, PACELLI FQ, MARCOLIN G, BIANCO A, PAOLI A. Twelve Months of Time-restricted Eating and Resistance Training Improves Inflammatory Markers and Cardiometabolic Risk Factors. Med Sci Sports Exerc. 2021;53(12):2577-2585. doi:10.1249/MSS.0000000000002738
Al-Rawi N, Madkour M, Jahrami H, et al. Effect of diurnal intermittent fasting during Ramadan on ghrelin, leptin, melatonin, and cortisol levels among overweight and obese subjects: A prospective observational study. PloS One. 2020;15(8):e0237922.
Cienfuegos S, Corapi S, Gabel K, et al. Effect of intermittent fasting on reproductive hormone levels in females and males: a review of human trials. Nutrients. 2022;14(11):2343.
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