The Diagnosis of Gestational Diabetes Mellitus: A Comprehensive Systematic Review
Keywords:
Diabetes mellitus, gestational, pregnancy, hyperglicemia, blood glucoseAbstract
Background: Gestational diabetes mellitus (GDM) is any degree of glucose intolerance with onset or first recognition during pregnancy. GDM can classify as A1GDM and A2GDM. Methods: This systematic review focused on full-text English literature published between 2014 and 2024 using the PRISMA 2020 guidelines. Editorials and review pieces published in the same
journal as the submission without a DOI were not accepted. The literature was compiled using PubMed, ScienceDirect, and SagePub, among other online venues. Result: Five publications were found to be directly related to our ongoing systematic examination after a rigorous three-level screening approach. Subsequently, a comprehensive analysis of the complete text was conducted, and additional scrutiny was given to these articles. Conclusion: Pregnancy insulin resistance or hypertriglyceridemia may be useful in GDM risk stratification. Future studies examining non-glycemic biochemical, genetic, other -omic, or sociocultural precision markers among women with GDM are warranted.
References
Francis EC, Powe CE, Lowe WL, White SL, Scholtens DM, Yang J, et al. Refining the diagnosis of gestational diabetes mellitus: a systematic review and meta-analysis. Commun Med [Internet]. 2023 Dec 18;3(1):185. Available from: https://www.nature.com/articles/s43856-023-00393-8
Sweeting A, Wong J, Murphy HR, Ross GP. A Clinical Update on Gestational Diabetes Mellitus. Endocr Rev. 2022;43(5):763–93.
Cleary EM, Thung SF, Buschur EO. Gestational Diabetes [Internet]. Endotext. 2000. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29370047
Zhu Y, Zhang C, Kennedy E. Prevalence of Gestational Diabetes and Risk of Progression to Type 2 Diabetes: a Global Perspective. Curr Diabetes. 2019;16(1):1–19.
Mishra S, Rao CR, Shetty A. Trends in the Diagnosis of Gestational Diabetes Mellitus. Scientifica (Cairo). 2016;2016.
Veerasamy S, Kapur A, Balaji V, Divakar H. A perspective on testing for gestational diabetes mellitus. Indian J Endocrinol Metab. 2015;19(4):529–32.
Moon JH, Jang HC. Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications. Diabetes Metab J. 2022;46(1):3–14.
Modzelewski R, Stefanowicz-Rutkowska MM, Matuszewski W, Bandurska-Stankiewicz EM. Gestational Diabetes Mellitus—Recent Literature Review. J Clin Med [Internet]. 2022 Sep 28;11(19):5736. Available from: https://www.mdpi.com/2077-0383/11/19/5736
Luewan S, Bootchaingam P, Tongsong T. Comparison of the Screening Tests for Gestational Diabetes Mellitus between “one-Step” and “two-Step” Methods among Thai Pregnant Wome. Obstet Gynecol Int. 2018;2018.
Dias T, Siraj SHM, Aris IM, Li LJ, Tan KH. Comparing different diagnostic guidelines for gestational diabetes mellitus in relation to birthweight in sri lankan women. Front Endocrinol (Lausanne). 2018;9(November):1–5.
Zaccara TA, Paganoti CF, Mikami FCF, Francisco RPV, Costa RA. Early vs. Late Gestational Diabetes: Comparison between Two Groups Diagnosed by Abnormal Initial Fasting Plasma Glucose or Mid-Pregnancy Oral Glucose Tolerance Test. Int J Environ Res Public Health. 2022;19(21).
Farrar D, Duley L, Dowswell T, Lawlor DA. Different strategies for diagnosing gestational diabetes to improve maternal and infant health. Cochrane Database Syst Rev. 2017;2017(8).
Sagili H, Kamalanathan S, Sahoo J, Lakshminarayanan S, Rani R, Jayalakshmi D, et al. Comparison of different criteria for diagnosis of gestational diabetes mellitus. Indian J Endocrinol Metab. 2015;19(6):824–8.
Quintanilla Rodriguez BS, Mahdy H. Gestational Diabetes [Internet]. StatPearls. 2024. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23536513
Plows JF, Stanley JL, Baker PN, Reynolds CM, Vickers MH. The pathophysiology of gestational diabetes mellitus. Int J Mol Sci. 2018;19(11):1–21.
Bhavadharini B, Uma R, Saravanan P, Mohan V. Screening and diagnosis of gestational diabetes mellitus - relevance to low and middle income countries. Clin Diabetes Endocrinol [Internet]. 2016;2(1):1–8. Available from: http://dx.doi.org/10.1186/s40842-016-0031-y
Nakshine VS, Jogdand SD. A Comprehensive Review of Gestational Diabetes Mellitus: Impacts on Maternal Health, Fetal Development, Childhood Outcomes, and Long-Term Treatment Strategies. Cureus. 2023;15(10).
Lende M, Rijhsinghani A. Gestational diabetes: Overview with emphasis on medical management. Int J Environ Res Public Health. 2020;17(24):1–12.
Reddi Rani P, Begum J. Screening and diagnosis of gestational diabetes mellitus, where do we stand. J Clin Diagnostic Res. 2016;10(4):QE01–4.
Sandu C, Bica C, Salmen T, Stoica R, Bohiltea R, Gherghiceanu F, et al. Gestational diabetes ‑ modern management and therapeutic approach (Review). Exp Ther Med. 2020;21(1):1–6.
Schäfer-Graf UM, Gembruch U, Kainer F, Groten T, Hummel S, Hösli I, et al. Gestational Diabetes Mellitus (GDM) - Diagnosis, Treatment and Follow-UpGuideline of the DDG and DGGG (S3 Level, AWMF Registry Number 057/008, February 2018). Geburtshilfe Frauenheilkd. 2018;78(12):1219–31.
Alfadhli EM. Gestational diabetes mellitus. Saudi Med J. 2015;36(4):399–406.
Tehrani FR, Naz MSG, Yarandi RB, Behboudi-Gandevani S. The impact of diagnostic criteria for gestational diabetes mellitus on adverse maternal outcomes: A systematic review and meta-analysis. J Clin Med. 2021;10(4):1–25.
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