Association of Metabolic Syndrome and Risk or Development of Chronic Kidney Disease
A Comprehensive Systematic Review
Keywords:
metabolic syndrome, chronic kidney disease, diagnosis, pathological characteristicAbstract
Background: Metabolic syndrome (MetS) encompasses a cluster of metabolic abnormalities including hypertension, hyperlipidemia, hyperuricemia, hyperglycemia, central obesity, and insulin resistance. MetS and chronic kidney disease (CKD) are intricately linked and can influence each other. This study aims to serve a comprehensive systematic review to evaluate the association of MetS and CKD in literatures of the last 10 years. Methods: The review adhered to PRISMA 2020 standards and analyzed full-text English literature from 2014 to 2024. It excluded editorials, review papers from the same journal, and submissions lacking a DOI. Literature sources included PubMed, SagePub, SpringerLink, and Google Scholar. Result: A total of 488 articles were retrieved from online databases (PubMed, SagePub, SpringerLink and Google Scholar). After three rounds of screening, five articles directly relevant to the systematic review were selected for full-text reading and analysis. Conclusion: The discussion emphasizes the complex link between metabolic syndrome (MetS) and chronic kidney disease (CKD), driven by modern lifestyle habits causing metabolic overload. Kidneys are especially susceptible to MetS effects, but effective treatment strategies are lacking. Further research is needed to understand and address MetS-related kidney damage.
References
Yanai H, Adachi H, Hakoshima M, Katsuyama H. Molecular Biological and Clinical Understanding of the Pathophysiology and Treatments of Hyperuricemia and Its Association with Metabolic Syndrome, Cardiovascular Diseases and Chronic Kidney Disease. International Journal of Molecular Sciences. 2021 Jan;22(17):9221.
Rao DP, Dai S, Lagace C, Krewski D. Metabolic syndrome and chronic disease. Chronic Diseases and Injuries in Canada. 2014;34(1).
Zhang D, Liu X, Liu Y, Sun X, Wang B, Ren Y, et al. Leisure-time physical activity and incident metabolic syndrome: a systematic review and dose-response meta-analysis of cohort studies. Metabolism. 2017 Oct 1;75:36–44.
Prasad GVR. Metabolic syndrome and chronic kidney disease: Current status and future directions. World J Nephrol. 2014 Nov 6;3(4):210–9.
Zhang X, Lerman LO. The metabolic syndrome and chronic kidney disease. Translational Research. 2017 May 1;183:14–25.
Lin L, Tan W, Pan X, Tian E, Wu Z, Yang J. Metabolic Syndrome-Related Kidney Injury: A Review and Update. Front Endocrinol [Internet]. 2022 Jun 23 [cited 2024 Apr 8];13. Available from: https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.904001/full
Cao Y, Deng Y, Wang J, Zhao H, Zhang J, Xie W. The association between NAFLD and risk of chronic kidney disease: a cross-sectional study. Therapeutic Advances in Chronic Disease. 2021 Jan 1;12:20406223211048649.
Kaps L, Labenz C, Galle PR, Weinmann-Menke J, Kostev K, Schattenberg JM. Non-alcoholic fatty liver disease increases the risk of incident chronic kidney disease. United European Gastroenterology Journal. 2020 Oct 1;8(8):942–8.
Chen SP, Li CR, Chang HC, Li YL, Pai HC. Relationship Between Metabolic Syndrome Severity and Kidney Function as Related to Gender: A Population-Based Longitudinal Study. Clin Nurs Res. 2020 Jul;29(6):355–62.
Raikou VD, Vlaseros G, Kyriaki D, Gavriil S. Serum Uric Acid and Coronary Arterial Disease in Predialysis Chronic Kidney Disease Patients. Indian Journal of Clinical Cardiology. 2022 Jun 1;3(2):73–81.
Zhang RN, Hao HF, Zhang W, Li Q, Ren LJ, Jia L, et al. Clinical characterization and prognostic implications of metabolic syndrome in patients undergoing peritoneal dialysis at a Chinese center. J Int Med Res. 2019 Nov 1;47(11):5573–83.
Lemieux I, Després JP. Metabolic Syndrome: Past, Present and Future. Nutrients. 2020 Nov;12(11):3501.
McCracken E, Monaghan M, Sreenivasan S. Pathophysiology of the metabolic syndrome. Clinics in Dermatology. 2018 Jan 1;36(1):14–20.
Sun DQ, Jin Y, Wang TY, Zheng KI, Rios RS, Zhang HY, et al. MAFLD and risk of CKD. Metabolism. 2021 Feb 1;115:154433.
Delanaye P, Jager KJ, Bökenkamp A, Christensson A, Dubourg L, Eriksen BO, et al. CKD: A Call for an Age-Adapted Definition. Journal of the American Society of Nephrology. 2019 Oct;30(10):1785.
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Copyright (c) 2024 Daniel Setiawan Nathan, Hoo Yumilia (Author)
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