The Analysis Study of Prevalence, Diagnosis and Management of Allergic Conjunctivitis: A Comprehensive Systematic Review
Keywords:
allergic conjunctivitis, prevalence, diagnosis, managementAbstract
Background: Allergic conjunctivitis (AC) is a common ocular condition that significantly impacts the quality of life of individuals worldwide. This systematic review aims to provide a comprehensive overview of the prevalence, diagnostic approaches, and management strategies for allergic conjunctivitis. Methods: The study followed PRISMA 2020 guidelines, reviewing English-language publications from 2014 to 2024. Editorials, duplicate reviews from the same journal, and papers lacking a DOI were excluded. The literature search was conducted using PubMed, SagePub, SpringerLink, and Google Scholar. Result: A total of 2,172 articles were initially identified through online databases (PubMed, SagePub, SpringerLink, and Google Scholar). After three rounds of screening, eight relevant studies were selected for full-text analysis. Conclusion: Allergic conjunctivitis is common and impacts quality of life. Management includes pharmacologic and non-pharmacologic treatments, with dual-acting antihistamine-mast cell stabilizers being key. Many remain undiagnosed or inadequately treated, highlighting the need for improved awareness, diagnostics, and future research.
References
Bielory L, Delgado L, Katelaris CH, Leonardi A, Rosario N, Vichyanoud P. ICON: diagnosis and management of allergic conjunctivitis. Ann Allergy Asthma Immunol. 2020;124(2):118-134.
Fauquert J. Diagnosing and managing allergic conjunctivitis in childhood: The allergist’s perspective. Pediatr Allergy Immunol. 2019;30(4):405-414. doi:10.1111/pai.13035
Miyazaki D, Fukagawa K, Okamoto S, et al. Epidemiological aspects of allergic conjunctivitis. Allergol Int. 2020;69(4):487-495.
Takamura E, Uchio E, Ebihara N, et al. Japanese guidelines for allergic conjunctival diseases 2017. Allergol Int. 2017;66(2):220-229.
Dupuis P, Prokopich CL, Hynes A, Kim H. A contemporary look at allergic conjunctivitis. Allergy Asthma Clin Immunol. 2020;16(1):5. doi:10.1186/s13223-020-0403-9
Gooderham M, McDonald J, Papp K. Diagnosis and Management of Conjunctivitis for the Dermatologist. J Cutan Med Surg. 2018;22(2):200-206. doi:10.1177/1203475417743233
Shoormasti RS, Pourpak Z, Fazlollahi MR, et al. The prevalence of allergic rhinitis, allergic conjunctivitis, atopic dermatitis and asthma among adults of Tehran. Iran J Public Health. 2018;47(11):1749.
Azari AA, Arabi A. Conjunctivitis: a systematic review. J Ophthalmic Vis Res. 2020;15(3):372.
Malu KN. Allergic conjunctivitis in jos-Nigeria. Niger Med J. 2014;55(2):166-170.
Miyazaki D, Takamura E, Uchio E, et al. Japanese guidelines for allergic conjunctival diseases 2020. Allergol Int. 2020;69(3):346-355.
Villegas BV, Benitez-del-Castillo JM. Current knowledge in allergic conjunctivitis. Turk J Ophthalmol. 2021;51(1):45.
Kumah DB, Lartey SY, Yemanyi F, Boateng EG, Awuah E. Prevalence of allergic conjunctivitis among basic school children in the Kumasi Metropolis (Ghana): a community-based cross-sectional study. BMC Ophthalmol. 2015;15(1):69. doi:10.1186/s12886-015-0053-8
Gomes PJ. Trends in prevalence and treatment of ocular allergy. Curr Opin Allergy Clin Immunol. 2014;14(5):451-456.
Scadding GK, Kariyawasam HH, Scadding G, et al. BSACI guideline for the diagnosis and management of allergic and non‐allergic rhinitis (Revised Edition 2017; First edition 2007). Clin Exp Allergy. 2017;47(7):856-889. doi:10.1111/cea.12953
Leung AK, Hon KL, Wong AH, Wong AS. Bacterial conjunctivitis in childhood: etiology, clinical manifestations, diagnosis, and management. Recent Pat Inflamm Allergy Drug Discov. 2018;12(2):120-127.
Andrade FMX, Picosse FR, Cunha LP da, et al. Ocular surface changes in the treatment of rosacea: comparison between low-dose oral isotretinoin and doxycycline. Arq Bras Oftalmol. 2020;83(2):109-112. doi:10.5935/0004-2749.20200016
Leonardi A, Piliego F, Castegnaro A, et al. Allergic conjunctivitis: a cross‐sectional study. Clin Exp Allergy. 2015;45(6):1118-1125. doi:10.1111/cea.12536
Blaiss MS, Dykewicz MS, Skoner DP, et al. Diagnosis and treatment of nasal and ocular allergies: the Allergies, Immunotherapy, and RhinoconjunctivitiS (AIRS) surveys. Ann Allergy Asthma Immunol. 2014;112(4):322-328.
Leonardi A, Palmigiano A, Mazzola EA, et al. Identification of human tear fluid biomarkers in vernal keratoconjunctivitis using iTRAQ quantitative proteomics. Allergy. 2014;69(2):254-260. doi:10.1111/all.12331
Bilkhu PS, Wolffsohn JS, Naroo SA, Robertson L, Kennedy R. Effectiveness of Nonpharmacologic Treatments for Acute Seasonal Allergic Conjunctivitis. Ophthalmology. 2014;121(1):72-78. doi:10.1016/j.ophtha.2013.08.007
Carr W, Schaeffer J, Donnenfeld E. Treating Allergic Conjunctivitis: A Once-daily Medication that Provides 24-hour Symptom Relief. Allergy Rhinol. 2016;7(2):ar.2016.7.0158. doi:10.2500/ar.2016.7.0158
Hara Y, Shiraishi A, Yamaguchi M, Kawasaki S, Uno T, Ohashi Y. Evaluation of Allergic Conjunctivitis by Thermography. Ophthalmic Res. 2014;51(3):161-166. doi:10.1159/000357105
MICHAILOPOULOS P, ALMALIOTIS D, GEORGIADOU I, et al. Allergic Conjunctivitis in Patients with Respiratory Allergic Symptoms; a Retrospective Study in Greece. Med Hypothesis Discov Innov Ophthalmol. 2017;6(1):3-9.
Siddiqui Z, Walker A, Pirwani M, Tahiri M, Syed I. Allergic rhinitis: diagnosis and management. Br J Hosp Med. 2022;83(2):1-9. doi:10.12968/hmed.2021.0570
Szyszkowicz M, Kousha T, Castner J. Air pollution and emergency department visits for conjunctivitis: A case-crossover study. doi:10.13075/ijomeh.1896.00442
Cheng L, Chen J, Fu Q, et al. Chinese society of allergy guidelines for diagnosis and treatment of allergic rhinitis. Allergy Asthma Immunol Res. 2018;10(4):300-353.
Yeu E, Hauswirth S. A Review of the Differential Diagnosis of Acute Infectious Conjunctivitis: Implications for Treatment and Management. Clin Ophthalmol. 2020;Volume 14:805-813. doi:10.2147/OPTH.S236571
Downloads
Published
Versions
- 2024-11-09 (2)
- 2024-11-24 (1)
Issue
Section
License
Copyright (c) 2024 Iffan Soffyan Ismail, Yuce Yuanita (Author)

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors publishing here keep copyright but grant the journal first publication rights, under a Creative Commons Attribution-NonCommercial 4.0 License. They can distribute their work non-exclusively elsewhere with an acknowledgment of its first publication in this journal. Posting the work online before and during submission for earlier and greater citation is encouraged, reflecting Open Access benefits.
