The Analysis Study of Surgical Approaches and Outcome in Living Donor Nephrectomy: A Comprehensive Systematic Review
Keywords:
nephrectomy, living donor, kidney donorAbstract
Background: The shortage of deceased donor kidneys has led to a significant increase in the use of living donor kidneys for transplantation. Since the first successful living donor nephrectomy in the 1950s, surgical techniques have advanced considerably, evolving from open donor nephrectomy (ODN) to more refined minimally invasive procedures. This systematic review aims to compare the various surgical techniques for living donor nephrectomy and their outcomes. Methods: The study followed PRISMA 2020 guidelines, reviewing English-language publications from 2014 to 2024. Editorials, duplicate reviews from the same journal, and papers lacking a DOI were excluded. The literature search was conducted using PubMed, SagePub, SpringerLink, and Google Scholar. Result: A total of 2,172 articles were initially identified through online databases (PubMed, SagePub, SpringerLink, and Google Scholar). After three rounds of screening, eight relevant studies were selected for full-text analysis. Conclusion: LDN and other minimally invasive techniques, such as RDN and robot-assisted nephrectomy, offer advantages in recovery time and reduced complications. However, each method has unique strengths and considerations. The choice of approach should depend on donor anatomy, surgeon expertise, and institutional resources.
References
Schold JD, Goldfarb DA, Buccini LD, et al. Hospitalizations following living donor nephrectomy in the United States. Clin J Am Soc Nephrol. 2014;9(2):355-365.
Autorino R, Brandao LF, Sankari B, et al. Laparoendoscopic single‐site ( LESS ) vs laparoscopic living‐donor nephrectomy: a systematic review and meta‐analysis. BJU Int. 2015;115(2):206-215. doi:10.1111/bju.12724
Janki S, Klop KWJ, Dooper IMM, Weimar W, Ijzermans JNM, Kok NFM. More than a decade after live donor nephrectomy: a prospective cohort study. Transpl Int. 2015;28(11):1268-1275. doi:10.1111/tri.12589
Vernadakis S, Marinaki S, Darema M, et al. The evolution of living donor nephrectomy program at a hellenic transplant center. Laparoscopic vs. open donor nephrectomy: single-center experience. J Clin Med. 2021;10(6):1195.
Lasorsa F, Orsini A, Bignante G, et al. Living Donor Nephrectomy: Analysis of Trends and Outcomes From a Contemporary National Dataset. Urology. Published online 2024. Accessed December 6, 2024. https://www.sciencedirect.com/science/article/pii/S0090429524008082
Kumar A, Chaturvedi S, Gulia A, Maheshwari R, Dassi V, Desai P. Laparoscopic live donor nephrectomy: comparison of outcomes right versus left. In: Transplantation Proceedings. Vol 50. Elsevier; 2018:2327-2332. Accessed December 6, 2024. https://www.sciencedirect.com/science/article/pii/S0041134518303671
Friedersdorff F, Kothmann L, Manus P, et al. Long-term donor outcomes after pure laparoscopic versus open living donor nephrectomy: focus on pregnancy rates, hypertension and quality of life. Urol Int. 2016;97(4):450-456.
Urology BS of, Silvinato A, Bernardo WM, Santos LS. Living donor nephrectomy. Rev Assoc Médica Bras. 2018;64(12):1061-1068.
Serrano OK, Kirchner V, Bangdiwala A, et al. Evolution of living donor nephrectomy at a single center: long-term outcomes with 4 different techniques in greater than 4000 donors over 50 years. Transplantation. 2016;100(6):1299-1305.
Windisch OL, Matter M, Pascual M, et al. Robotic versus hand-assisted laparoscopic living donor nephrectomy: comparison of two minimally invasive techniques in kidney transplantation. J Robot Surg. 2022;16(6):1471-1481. doi:10.1007/s11701-022-01393-x
Zaytoun O, Elsawy M, Ateba K, Khalifa A, Hamdy A, Mostafa A. Laparoscopic donor nephrectomy: technique and outcome, a single-center experience. Afr J Urol. 2021;27(1):151. doi:10.1186/s12301-021-00254-7
Garcia-Ochoa C, Feldman LS, Nguan C, et al. Perioperative Complications During Living Donor Nephrectomy: Results From a Multicenter Cohort Study. Can J Kidney Health Dis. 2019;6:2054358119857718. doi:10.1177/2054358119857718
Achit H, Guillemin F, Karam G, et al. Cost-effectiveness of four living-donor nephrectomy techniques from a hospital perspective. Nephrol Dial Transplant. 2020;35(11):2004-2012.
Burkhalter F, Huynh-Do U, Hadaya K, et al. Early complications after living donor nephrectomy: analysis of the Swiss Organ Living Donor Health Registry. Swiss Med Wkly. 2017;147. Accessed December 6, 2024. https://serval.unil.ch/resource/serval:BIB_9735921D139A.P001/REF.pdf
Musquera M, Peri L, D’Anna M, et al. Outcomes after 20 years of experience in minimally invasive living-donor nephrectomy. World J Urol. 2022;40(3):807-813. doi:10.1007/s00345-021-03912-1
Khalil A, Mujtaba MA, Taber TE, et al. Trends and outcomes in right vs. left living donor nephrectomy: an analysis of the OPTN/UNOS database of donor and recipient outcomes – should we be doing more right-sided nephrectomies? Clin Transplant. 2016;30(2):145-153. doi:10.1111/ctr.12668
Fonouni H, Mehrabi A, Golriz M, et al. Comparison of the laparoscopic versus open live donor nephrectomy: an overview of surgical complications and outcome. Langenbecks Arch Surg. 2014;399(5):543-551. doi:10.1007/s00423-014-1196-4
Kortram K, Ijzermans JN, Dor FJ. Perioperative events and complications in minimally invasive live donor nephrectomy: a systematic review and meta-analysis. Transplantation. 2016;100(11):2264-2275.
Giacomoni A, Di Sandro S, Lauterio A, et al. Robotic nephrectomy for living donation: surgical technique and literature systematic review. Am J Surg. 2016;211(6):1135-1142.
Creta M, Calogero A, Sagnelli C, et al. Donor and Recipient Outcomes following Robotic-Assisted Laparoscopic Living Donor Nephrectomy: A Systematic Review. BioMed Res Int. 2019;2019:1-10. doi:10.1155/2019/1729138
Calpin GG, Hehir C, Davey MG, MacCurtain BM, Little D, Davis NF. Right and left living donor nephrectomy and operative approach: a systematic review and meta-analysis of donor and recipient outcomes. Transplant Rev. Published online 2024:100880.
Dagnæs-Hansen J, Kristensen GH, Stroomberg HV, Sørensen SS, Røder MA. Surgical Approaches and Outcomes in Living Donor Nephrectomy: A Systematic Review and Meta-analysis. Eur Urol Focus. 2022;8(6):1795-1801. doi:10.1016/j.euf.2022.03.021
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Adzana Yasadhy Hangga Prasetyo, Yosie Yulanda Putra (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors publishing here keep copyright but grant the journal first publication rights, under a Creative Commons Attribution-NonCommercial 4.0 License. They can distribute their work non-exclusively elsewhere with an acknowledgment of its first publication in this journal. Posting the work online before and during submission for earlier and greater citation is encouraged, reflecting Open Access benefits.
