The Analysis Study of Effect of Maternal Calcium Supplementation And Pediatric Health : A Comprehensive Systematic Review
Keywords:
calcium supplementation, maternal, pediatric healthAbstract
Background: Maternal calcium supplementation significantly impacts pediatric health, influencing growth and development. However, the effects on bone growth and mineralization remain inconsistent. Research in low habitual calcium intake populations shows sex-specific outcomes. Pregnancy-induced calcium supplementation has mixed outcomes, with increased mobilization during lactation and minimal impact on offspring growth. Further investigation is needed to improve pediatric health outcomes in diverse dietary calcium intakes. Methods: This systematic review was conducted in strict compliance with the PRISMA 2020 guidelines, ensuring methodological rigor and transparency. The review included only full-text articles published in English between 2013 and 2024, with a focus on high-quality sources. Editorials and review articles lacking a DOI were excluded to maintain the integrity and reliability of the dataset. An extensive literature search was performed using reputable databases, including ScienceDirect, PubMed, and SagePub, to identify studies relevant to the research objectives. Result: The initial database search yielded over 100 publications. Through a rigorous three-stage screening process, eight studies were carefully selected for inclusion based on their relevance and adherence to the established criteria. These selected studies underwent a thorough and critical analysis, offering a detailed evaluation of the impact of maternal calcium supplementation on pediatric health outcomes. Conclusion: Calcium supplementation is crucial for maternal and fetal health during pregnancy, reducing risks like gestational hypertension and pre-eclampsia. World Health Organization recommends 1500-2000 mg daily. Further research is needed to understand sex-specific growth patterns and IGF1-related pathways.
References
Winzenberg, T., Shaw, K., Fryer, J., & Jones, G. (2006). Effects of calcium supplementation on bone density in healthy children: meta-analysis of randomised controlled trials. BMJ (Clinical research ed.), 333(7572), 775. https://doi.org/10.1136/bmj.38950.561400.55
Ward K. (2012). Musculoskeletal phenotype through the life course: the role of nutrition. The Proceedings of the Nutrition Society, 71(1), 27–37. https://doi.org/10.1017/S0029665111003375
Roberfroid, D., Huybregts, L., Lanou, H., Henry, M. C., Meda, N., Kolsteren F, P., & Micronutriments et Santé de la Mère et de l'Enfant Study (MISAME) Group (2010). Effect of maternal multiple micronutrient supplements on cord blood hormones: a randomized controlled trial. The American journal of clinical nutrition, 91(6), 1649–1658. https://doi.org/10.3945/ajcn.2009.28855
Rosenfeld C. S. (2015). Sex-Specific Placental Responses in Fetal Development. Endocrinology, 156(10), 3422–3434. https://doi.org/10.1210/en.2015-1227
Dibba, B., Prentice, A., Ceesay, M., Mendy, M., Darboe, S., Stirling, D. M., Cole, T. J., & Poskitt, E. M. (2002). Bone mineral contents and plasma osteocalcin concentrations of Gambian children 12 and 24 mo after the withdrawal of a calcium supplement. The American journal of clinical nutrition, 76(3), 681–686. https://doi.org/10.1093/ajcn/76.3.681
Prentice, A., Dibba, B., Sawo, Y., & Cole, T. J. (2012). The effect of prepubertal calcium carbonate supplementation on the age of peak height velocity in Gambian adolescents. The American journal of clinical nutrition, 96(5), 1042–1050. https://doi.org/10.3945/ajcn.112.037481
Ward, K. A., Cole, T. J., Laskey, M. A., Ceesay, M., Mendy, M. B., Sawo, Y., & Prentice, A. (2014). The effect of prepubertal calcium carbonate supplementation on skeletal development in Gambian boys-a 12-year follow-up study. The Journal of clinical endocrinology and metabolism, 99(9), 3169–3176. https://doi.org/10.1210/jc.2014-1150
Jarjou, L. M., Laskey, M. A., Sawo, Y., Goldberg, G. R., Cole, T. J., & Prentice, A. (2010). Effect of calcium supplementation in pregnancy on maternal bone outcomes in women with a low calcium intake. The American journal of clinical nutrition, 92(2), 450–457. https://doi.org/10.3945/ajcn.2010.29217
Jarjou, L. M., Sawo, Y., Goldberg, G. R., Laskey, M. A., Cole, T. J., & Prentice, A. (2013). Unexpected long-term effects of calcium supplementation in pregnancy on maternal bone outcomes in women with a low calcium intake: a follow-up study. The American journal of clinical nutrition, 98(3), 723–730. https://doi.org/10.3945/ajcn.113.061630
Jarjou, L. M., Prentice, A., Sawo, Y., Laskey, M. A., Bennett, J., Goldberg, G. R., & Cole, T. J. (2006). Randomized, placebo-controlled, calcium supplementation study in pregnant Gambian women: effects on breast-milk calcium concentrations and infant birth weight, growth, and bone mineral accretion in the first year of life. The American journal of clinical nutrition, 83(3), 657–666. https://doi.org/10.1093/ajcn.83.3.657
Goldberg, G. R., Jarjou, L. M., Cole, T. J., & Prentice, A. (2013). Randomized, placebo-controlled, calcium supplementation trial in pregnant Gambian women accustomed to a low calcium intake: effects on maternal blood pressure and infant growth. The American journal of clinical nutrition, 98(4), 972–982. https://doi.org/10.3945/ajcn.113.059923
Ward, K. A., Jarjou, L., & Prentice, A. (2017). Long-term effects of maternal calcium supplementation on childhood growth differ between males and females in a population accustomed to a low calcium intake. Bone, 103, 31–38. https://doi.org/10.1016/j.bone.2017.06.001
Jamshidi, F., & Kelishadi, R. (2015). A systematic review on the effects of maternal calcium supplementation on offspring's blood pressure. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 20(10), 994–999. https://doi.org/10.4103/1735-1995.172794
Prentice, A., Ward, K. A., Nigdikar, S., Hawkesworth, S., & Moore, S. E. (2019). Pregnancy supplementation of Gambian mothers with calcium carbonate alters mid-childhood IGF1 in a sex-specific manner. Bone, 120, 314–320. https://doi.org/10.1016/j.bone.2018.11.011
Korhonen, P., Tihtonen, K., Isojärvi, J., Ojala, R., Ashorn, U., Ashorn, P., & Tammela, O. (2022). Calcium supplementation during pregnancy and long-term offspring outcome: a systematic literature review and meta-analysis. Annals of the New York Academy of Sciences, 1510(1), 36–51. https://doi.org/10.1111/nyas.14729
Tihtonen, K., Korhonen, P., Isojärvi, J., Ojala, R., Ashorn, U., Ashorn, P., & Tammela, O. (2022). Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta-analysis. Annals of the New York Academy of Sciences, 1509(1), 23–36. https://doi.org/10.1111/nyas.14705
Prentice, A., Jarjou, L. M., Goldberg, G. R., Schoenbuchner, S. M., Moore, S. E., Ward, K. A., & Cole, T. J. (2024). Effects of maternal calcium supplementation on offspring blood pressure and growth in childhood and adolescence in a population with a low-calcium intake: follow-up study of a randomized controlled trial. The American journal of clinical nutrition, 119(6), 1443–1454. https://doi.org/10.1016/j.ajcnut.2024.02.025
Prentice, A. (2000). Calcium in Pregnancy and Lactation. Annual Review of Nutrition, 20(1), 249–272. https://doi.org/10.1146/annurev.nutr.20.1.249
Cormick, G., Betrán, A. P., Romero, I. B., Lombardo, C. F., Gülmezoglu, A. M., Ciapponi, A., & Belizán, J. M. (2019). Global inequities in dietary calcium intake during pregnancy: a systematic review and meta-analysis. BJOG : an international journal of obstetrics and gynaecology, 126(4), 444–456. https://doi.org/10.1111/1471-0528.15512
Woo Kinshella, M. L., Sarr, C., Sandhu, A., Bone, J. N., Vidler, M., Moore, S. E., Elango, R., Cormick, G., Belizan, J. M., Hofmeyr, G. J., Magee, L. A., von Dadelszen, P., & PRECISE Network (2022). Calcium for pre-eclampsia prevention: A systematic review and network meta-analysis to guide personalised antenatal care. BJOG : an international journal of obstetrics and gynaecology, 129(11), 1833–1843. https://doi.org/10.1111/1471-0528.17222
Belizán, J. M., Villar, J., Bergel, E., del Pino, A., Di Fulvio, S., Galliano, S. V., & Kattan, C. (1997). Long-term effect of calcium supplementation during pregnancy on the blood pressure of offspring: follow up of a randomised controlled trial. BMJ (Clinical research ed.), 315(7103), 281–285. https://doi.org/10.1136/bmj.315.7103.281
Hatton, D. C., Harrison-Hohner, J., Coste, S., Reller, M., & McCarron, D. (2003). Gestational calcium supplementation and blood pressure in the offspring. American journal of hypertension, 16(10), 801–805. https://doi.org/10.1016/s0895-7061(03)01027-6
Chen, X., & Wang, Y. (2008). Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis. Circulation, 117(25), 3171–3180. https://doi.org/10.1161/CIRCULATIONAHA.107.730366
Cham, B., Scholes, S., Ng Fat, L., Badjie, O., & Mindell, J. S. (2018). Burden of hypertension in The Gambia: evidence from a national World Health Organization (WHO) STEP survey. International journal of epidemiology, 47(3), 860–871. https://doi.org/10.1093/ije/dyx279
Rose G. (1981). Strategy of prevention: lessons from cardiovascular disease. British medical journal (Clinical research ed.), 282(6279), 1847–1851. https://doi.org/10.1136/bmj.282.6279.1847
Stamler, R., Stamler, J., Gosch, F. C., Civinelli, J., Fishman, J., McKeever, P., McDonald, A., & Dyer, A. R. (1989). Primary prevention of hypertension by nutritional-hygienic means. Final report of a randomized, controlled trial. JAMA, 262(13), 1801–1807.
Ben-Shlomo, Y., Holly, J., McCarthy, A., Savage, P., Davies, D., & Davey Smith, G. (2005). Prenatal and postnatal milk supplementation and adult insulin-like growth factor I: long-term follow-up of a randomized controlled trial. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 14(5), 1336–1339. https://doi.org/10.1158/1055-9965.EPI-04-0908
Hrolfsdottir, L., Rytter, D., Hammer Bech, B., Brink Henriksen, T., Danielsen, I., Steingrimsdottir, L., Olsen, S. F., & Halldorsson, T. I. (2013). Maternal milk consumption, birth size and adult height of offspring: a prospective cohort study with 20 years of follow-up. European journal of clinical nutrition, 67(10), 1036–1041. https://doi.org/10.1038/ejcn.2013.151
Tarrade, A., Panchenko, P., Junien, C., & Gabory, A. (2015). Placental contribution to nutritional programming of health and diseases: epigenetics and sexual dimorphism. The Journal of experimental biology, 218(Pt 1), 50–58. https://doi.org/10.1242/jeb.110320
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Ferianis Setiawati, Anis Prima Dewi Anis Prima Dewi (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors publishing here keep copyright but grant the journal first publication rights, under a Creative Commons Attribution-NonCommercial 4.0 License. They can distribute their work non-exclusively elsewhere with an acknowledgment of its first publication in this journal. Posting the work online before and during submission for earlier and greater citation is encouraged, reflecting Open Access benefits.
