Complications of Recurrent Corticosteroid Use in Patients with Erythema Nodosum Leprosum : A Case Report
Keywords:
Complications, corticosteroids, erythema nodosum leprosum, morbus hansen, osteoporosisAbstract
The use of corticosteroids is the standard therapy for managing leprosy reactions. However, long-term corticosteroid use can cause various complications. This case report discusses the potential complications of long-term corticosteroid use in a patient with Hansen's disease (MH) and erythema nodosum leprosum (ENL) reactions. This case report emphasizes the importance of routine monitoring in patients receiving corticosteroids to detect and manage potential complications.
References
Sugumaran D. Leprosy Reactions - Complications of Steroid Therapy. International Journal of Leprosy and Other Mycobacterial Diseases, (1998), 66(1).
National Hansen’s Disease (Leprosy) Program Caring and Curing Since 1894. Diakses Pada 3 Oktober 2023 dari https://www.hrsa.gov/hansens-disease/diagnosis/reactions
Siagian,J. N., Purwantyastuti, Instiaty, & Menaldi, S. L. (2022). Analysis of therapeutic effectiveness and adverse effects of long-term corticosteroids among leprosy patients with reactions: A retrospective cohort study. SAGE Open Medicine, 10.
Listiyawati IT, Sawitri, Agusni I, Prakoeswa CRS. Terapi Kortikosteroid Oral pada pasien Baru Kusta dengan Reaksi Tipe 2. 2015;27(1):48-5
Spitz CN, Pitta LJR, Andrade LR, et al. Injected corticosteroids for treating leprosy isolated neuritis. Frontiers in Medicine. 2023:1-6
Wisnu IM, Sjamsoe-Daili ES, Menaldi SL. Ilmu penyakit kulit dan kelamin. 7th ed. Jakarta: Fakultas Kedokteran Universitas Indonesia; 2015.
Kahawita IP, Walker SL, Lockwood DN. Leprosy type 1 reactions and erythema nodosum leprosum. An Bras Dermatol. 2008,83:75-82.
Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ. Fitzpatrick's dermatology in general medicine. 8th ed. Philadelphia: McGraw-Hill; 2014.
James WD, Berger T, Elston D. Andrews' diseases of the skin. 12th ed. San Fransisco: Elsevier; 2015
Anggraini, S., Esti, P., & Komarasari, E. (2022). TERAPI ALTERNATIF REAKSI KUSTA. Media Dermato Venereologica Indonesiana, 48(4). https://doi.org/10.33820/mdvi.v48i4.304
Kobza, C. E., & Binkley, N. (2021). Understanding and Managing Corticosteroid-Induced Osteoporosis. Current Osteoporosis
New York State Department of Health. (2023, September 21). What You Should Know About Steroids and Osteoporosis. Diakses pada tanggal 8 Oktober 2023, dari https://www.health.ny.gov/publications/1985/index.htm
Royal Osteoporosis Society. (2023, September 21). Steroid treatments and osteoporosis risk. Diakses pada tanggal 8 Oktober 2023, dari https://theros.org.uk/information-and support/osteoporosis/causes/steroids
New York State Department of Health. (2023, September 21). What You Should Know About Steroids and Osteoporosis. Diakses pada tanggal 8 Oktober 2023, dari https://www.health.ny.gov/publications/1985/index.htm
Briot K, Roux C. Glucocorticoid-induced osteoporosis. RMD Open. 2015;1(1):e000014. doi:10.1136/rmdopen-2014-000014
Setyorini A, Suandi IKG, Sidiartha IGL, Suryawan WB. Pencegahan osteoporosis dengan suplementasi kalsium dan vitamin D pada penggunaan kortikosteroid jangka panjang. Saripediatri.2009;11(1):32-8
Prakash NK, Raghuveer C, Murthy SC et al (2021). Corticosteroid Induced Osteoporosis Leading to Fracture Neck Femur in a Case of Type 2 Lepra Reaction. Indian J Lepr. 93: 319-22
Voorend CGN, Post EB. A Systematic review on the epidemiological data of erythema nodosum leprosum, a type 2 leprosy reaction. PLoS Negl Trop Dis. 2013;7(10):e2440.
Kumar B and Kar H. IAL Textbook of Leprosy. 2017. 2nd ed. New Delhi. Jaypee Brothers Medical Publishers (P) Ltd.
Pocaterra L, Jain S, Reddy R, Muzaffarullah S, Torres O, Suneetha S & Lockwood DN. (2006). Clinical course of erythema nodosum leprosum: an 11-year cohort study in Hyderabad, India. The American journal of tropical medicine and hygiene, 74(5), 868-879.
Walker SL, Waters MF, Lockwood DN. (2007). The role of thalidomide in the management of erythema nodosum leprosum. Leprosy review, 78(3), 197.
Sampaio EP, Sarno EN, Galilly R, Cohn ZA, Kaplan G. (1991). Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes. Journal of Experimental Medicine, 173(3), 699-703.
Schäcke H, Döcke WD, Asadullah K. (2002). Mechanisms involved in the side effects of glucocorticoids. Pharmacology & therapeutics, 96(1), 23-43
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