The Analysis Study of Prevalence, Management and Outcome of Thalassemia in Children : A Comprehensive Systematic Review
Keywords:
Thalassemia, children, mutation, hemoglobinAbstract
Background: Thalassemia is an inherited autosomal recessive disease resulting from mutations in the α- and β-globin gene clusters on chromosome 16 and chromosome 11, respectively. The aim of this study to show about prevalence, management and outcome of thalassemia in children. Methods: By the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. Result: Eight publications were found to be directly related to our ongoing systematic examination after a rigorous three-level screening approach. Subsequently, a comprehensive analysis of the complete text was conducted, and additional scrutiny was given to these articles. Conclusion: The prevalence and gene mutation spectrum of thalassemia display obviously heterogeneity among children. The findings provide the valuable information for premarital and pre-pregnancy screening, prenatal diagnostic services, and designing appropriate prevention programs to control thalassemia for future.
References
Bajwa H, Basit H. Thalassemia [Internet]. StatPearls. 2024. Available from: http://www.ncbi.nlm.nih.gov/pubmed/31119181
Hossain MS, Raheem E, Sultana TA, Ferdous S, Nahar N, Islam S, et al. Thalassemias in South Asia: clinical lessons learnt from Bangladesh. Orphanet J Rare Dis. 2017;12(1):1–9.
Farmakis D, Porter J, Taher A, Cappellini MD, Angastiniotis M, Eleftheriou A, et al. 2021 Thalassaemia International Federation Guidelines for the Management of Transfusion-dependent Thalassemia. HemaSphere. 2022;6(8).
Goh LPW, Chong ETJ, Lee PC. Prevalence of alpha(α)-thalassemia in Southeast Asia (2010–2020): A meta-analysis involving 83,674 subjects. Int J Environ Res Public Health. 2020;17(20):1–11.
Yousuf R, Akter S, Wasek SM, Sinha S, Ahmad R, Haque M. Thalassemia: A Review of the Challenges to the Families and Caregivers. Cureus. 2022;14(12):8–15.
Staikou C, Stavroulakis E, Karmaniolou I. A narrative review of peri-operative management of patients with thalassaemia. Anaesthesia. 2014;69(5):494–510.
Angastiniotis M, Lobitz S. Thalassemias: An overview. Int J Neonatal Screen. 2019;5(1):1–11.
Chonat S, Quinn CT. Current standards of care and long term outcomes for thalassemia and sickle cell disease. Adv Exp Med Biol. 2017;1013:59–87.
Shafie AA, Chhabra IK, Wong JHY, Mohammed NS, Ibrahim HM, Alias H. Health-related quality of life among children with transfusion-dependent thalassemia: A cross-sectional study in Malaysia. Health Qual Life Outcomes. 2020;18(1):1–11.
Seyedifar M, Dorkoosh FA, Hamidieh AA, Naderi M, Karami H, Karimi M, et al. Health-related quality of life and health utility values in beta thalassemia major patients receiving different types of iron chelators in Iran. Int J Hematol Stem Cell Res. 2016;10(4):224–31.
Hakeem GLA, Mousa SO, Moustafa AN, Mahgoob MH, Hassan EE. Health-related quality of life in pediatric and adolescent patients with transfusion-dependent ß-thalassemia in upper Egypt (single center study). Health Qual Life Outcomes. 2018;16(1):1–9.
Saleem N, Anwar A, Shahid NUA, Saleem R, Saleem Z, Asghar H, et al. Perception of Parents of Thalassemic Child to Thalassemia in Pakistan. Cureus. 2021;13(8):6–10.
Lee HJ, Shin KH, Kim HH, Yang EJ, Park KH, Kim MJ, et al. Increased prevalence of thalassemia in young people in Korea: Impact of increasing immigration. Ann Lab Med. 2019;39(2):133–40.
Trehan A, Sharma N, Das R, Bansal D, Marwaha RK. Clinicoinvestigational and Demographic Profile of Children with Thalassemia Major. Indian J Hematol Blood Transfus. 2015;31(1):121–6.
Tubman VN, Fung EB, Vogiatzi M, Thompson AA, Rogers ZR, Neufeld EJ, et al. Guidelines for the Standard Monitoring of Patients With Thalassemia. J Pediatr Hematol Oncol. 2015;37(3):e162–9.
Lai K, Huang G, Su L, He Y. The prevalence of thalassemia in mainland China: Evidence from epidemiological surveys. Sci Rep. 2017;7(1):1–11.
Harewood J, Azevedo AM. Alpha Thalassemia [Internet]. StatPearls. 2024. Available from: http://www.ncbi.nlm.nih.gov/pubmed/30673812
MacKenzie TC, Amid A, Angastiniotis M, Butler C, Gilbert S, Gonzalez J, et al. Consensus statement for the perinatal management of patients with a thalassemia major. Blood Adv. 2021;5(24):5636–9.
Fibach E, Rachmilewitz EA. Pathophysiology and treatment of patients with beta-thalassemia - an update. F1000Research. 2017;6(0).
Motiani A, Zubair M, Sonagra AD. Laboratory Evaluation of Alpha Thalassemia [Internet]. StatPearls. 2024. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28651846
Macharia AW, Mochamah G, Makale J, Howard T, Mturi N, Olupot-Olupot P, et al. Case Report: β-thalassemia major on the East African coast. Wellcome Open Res. 2022;7:1–8.
Huang TL, Zhang TY, Song CY, Lin YB, Sang BH, Lei QL, et al. Gene Mutation Spectrum of Thalassemia Among Children in Yunnan Province. Front Pediatr. 2020;8(April):1–5.
Xu X, Wu X. Epidemiology and treatment of beta thalassemia major in China. Pediatr Investig. 2020;4(1):43–7.
Lal A, Wong T, Keel S, Pagano M, Chung J, Kamdar A, et al. The transfusion management of beta thalassemia in the United States. Transfusion. 2021;61(10):3027–39.
Pang D, Shang X, Cai D, Yang F, Lu H, Cheng Y, et al. Unusual survival of a twin with homozygous α0-thalassemia due to chimerism. Haematologica. 2021;106(5):1507–10.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Muhammad Irwanto, Khoirunnida, Kartika Istiningtyas (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors publishing here keep copyright but grant the journal first publication rights, under a Creative Commons Attribution-NonCommercial 4.0 License. They can distribute their work non-exclusively elsewhere with an acknowledgment of its first publication in this journal. Posting the work online before and during submission for earlier and greater citation is encouraged, reflecting Open Access benefits.
