A Preventable Cascade: Severe Acute Malnutrition and Bilateral Pneumonia in a Young Infant with Unrecognized Feeding Dysfunction due to Labiopalatoschizis
Keywords:
severe acute malnutrition, pneumonia, cleft lip and palate, feeding dysfunction, infant nutritionAbstract
Introduction: Severe acute malnutrition and pneumonia remain leading contributors to infant morbidity and mortality, particularly in resource-limited settings. Infants with cleft lip and palate are at risk of feeding dysfunction, which may precipitate nutritional decline if not promptly recognized.
Case Illustration: A 1-month-26-day-old male infant with complete unilateral labiopalatoschizis presented with progressive shortness of breath and hypoxemia. Anthropometry revealed weight-for-age, length-for-age, and weight-for-length below –3 SD, consistent with severe acute malnutrition of the marasmic type. Feeding history demonstrated inadequate intake and frequent choking without structured feeding modification. Laboratory findings showed anemia and leukocytosis, and chest radiography confirmed bilateral pneumonia. Management included oxygen therapy, intravenous antibiotics, and phased nutritional rehabilitation via orogastric feeding.
Discussion: This case illustrates a preventable cascade in which structural feeding impairment led to chronic caloric insufficiency, immune compromise, and severe respiratory infection. The interaction between malnutrition and pneumonia amplified clinical severity. Early feeding counseling and routine growth monitoring might have prevented progression to severe wasting and infection.
Conclusion: Infants with labiopalatoschizis require early structured feeding support and close nutritional surveillance to prevent severe acute malnutrition and life-threatening complications such as pneumonia.
References
World Health Organization. The UNICEF-WHO-World Bank Joint Child Malnutrition Estimates (JME) standard methodology: tracking progress on SDG Indicators 2.2. 1 on stunting, 2.2. 2 (1) on overweight and 2.2. 2 (2) on wasting. World Health Organization; 2024.
Micha R, Di Cesare M, Ghosh S, Zanello G. 2022 global nutrition report: stronger commitments for Greater Action. Bristol, UK: Developmental Initiatives. 2022;
Bourke CD, Berkley JA, Prendergast AJ. Immune Dysfunction as a Cause and Consequence of Malnutrition. Trends Immunol. 2016 Jun;37(6):386–98.
Li Y, Wang X, Blau DM, Caballero MT, Feikin DR, Gill CJ, et al. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis. Lancet. 2022 May 28;399(10340):2047–64.
Tickell KD, Denno DM. Inpatient management of children with severe acute malnutrition: a review of WHO guidelines. Bull World Health Organ. 2016 Sep 1;94(9):642–51.
Macpherson L, Ogero M, Akech S, Aluvaala J, Gathara D, Irimu G, et al. Risk factors for death among children aged 5-14 years hospitalised with pneumonia: a retrospective cohort study in Kenya. BMJ Glob Health. 2019;4(5):e001715.
Salari N, Darvishi N, Heydari M, Bokaee S, Darvishi F, Mohammadi M. Global prevalence of cleft palate, cleft lip and cleft palate and lip: A comprehensive systematic review and meta-analysis. J Stomatol Oral Maxillofac Surg. 2022 Apr;123(2):110–20.
Penny C, McGuire C, Bezuhly M. A Systematic Review of Feeding Interventions for Infants with Cleft Palate. Cleft Palate Craniofac J. 2022 Dec;59(12):1527–36.
Williams JL, Lien KM, Kirschner R, Allen G, Chapman K, Cleft Outcomes Research NETwork (CORNET) Consortium. Feeding Management and Palate Repair Timing in Infants with Cleft Palate with and without Pierre Robin Sequence: A Multisite Study. Cleft Palate Craniofac J. 2025 Jul;62(7):1180–9.
Kinter S, Meehan A, Ormanidou I, Heike CL, Nylander E, Rahman M, et al. Systematic Review of Growth in Young Children With Cleft Lip and/or Cleft Palate From 0 to 24 Months of Age. Cleft Palate Craniofac J. 2025 Aug 12;10556656251365012.
Mattiello V, Schmugge M, Hengartner H, von der Weid N, Renella R, SPOG Pediatric Hematology Working Group. Diagnosis and management of iron deficiency in children with or without anemia: consensus recommendations of the SPOG Pediatric Hematology Working Group. Eur J Pediatr. 2020 Apr;179(4):527–45.
Kaiser JK, Kamble RH, Nambiar K, Nerurkar S, Suchak D. Comprehensive Multidisciplinary Management of Bilateral Cleft Lip and Palate. Cureus. 2024 Jan;16(1):e52643.
Bhutta ZA, Das JK, Rizvi A, Gaffey MF, Walker N, Horton S, et al. Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost? Lancet. 2013 Aug 3;382(9890):452–77.
Gera T, Shah D, Garner P, Richardson M, Sachdev HS. Integrated management of childhood illness (IMCI) strategy for children under five. Cochrane database of systematic reviews. 2016;(6).
Hidayatullah H, Pertiwi ASP, Husyaerry MA. The use of feeding plate to improve weight gain in infants with cleft palate during surgical preparation: a case report. Padjadjaran J Dent. 2025 May 15;37(1):105–10.
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